Ion Channel Studies
Chloride Channels
Flexible assay formats
Leveraging fluorescence-based and electrophysiology platforms, SB Drug Discovery’s experienced ion channel team specializes in assays tailored specifically for investigating chloride channels and characterization of chloride channel modulators. Our flexible approach accommodates assay conditions suited to your discovery requirements.
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Chloride Channel Electrophysiology
Figure 1: Representative CLC-1 current traces in the presence of an increasing concentration of the channel blocker 9-AC. Currents were evoked using a double-pulse protocol from a holding potential of -100 mV, the first step was made to +100 mV for 300 ms and the second step was made to -125 mV for 300 ms.
Case Study
Electrophysiological characterization of human CLC-1 and CLC-2 ion channels
Electrophysiological Characterization of Functional and Pharmacological Effects of CLC-1 and CLC-2 Channel Activity.
