Ion Channel Studies
TRP Channels
Flexible assay formats
SB Drug Discovery’s flexible assay formats offer an extensive range of optimized TRP channel assays, providing accurate, reliable data without the challenges of in-house development. Leveraging this adaptability, our scientists support rapid hit identification and investigation into TRP channel cross-reactivity, enabling efficient exploration and identification of novel, target-selective compounds. This flexible approach empowers drug discovery efforts with tailored solutions designed to meet unique research needs and accelerate project timelines.
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TRPA1 Electrophysiology
Figure 1: Representative TRPA1 current traces before (grey line) and during the presence of increasing concentrations of the blocker A967079 (blue lines). A 300 ms ramp protocol from -60 mV to +60 mV, from a holding potential of +0 mV and repeated every 30 seconds is used to monitor the TRPA1 current.
Case Study
TRPML1 Electrophysiology
Transient Receptor Potential (TRP) channels are essential for regulating cellular excitability and intracellular calcium levels.
